• Avanafil 100 mg

Avanafil 100 mg

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Generic Avanafil Tablets (Avana) - Product Information

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Avana (Generic Avanafil tablets) which contains the active substance Avanafil is used as a treatment for adult men suffering from erectile dysfunction (also known as ED or impotence). ED is a medical condition in men characterised by an inability to get or keep a hard, erect penis suitable for sexual activity. Avanafil Tablets belong to a group of medicines called phosphodiesterase type 5 (PDE5) inhibitors.

Avana tablets (Generic Stendra) are manufactured by Sunrise Remedies Pvt. Ltd., India in the strengths of 50 mg and 100 mg.

Name of the Drug

We supply original Avana tablets manufactured by Sunrise Remedies Pvt. Ltd. .

Manufacturer of Tablets

Sunrise Remedies Pvt. Ltd.  
Website: www.sunriseremedies.in

Active Ingredient present in Avana Tablets

The active ingredient present in Avana tablets is Avanafil. Each Avana tablet contains 50 mg or 100 mg of Avanafil.

Avanafil Dosage

Avanafil (Generic Stendra) comes as a tablet to take by mouth. The starting dose of Generic Avanafil Tablets (Avana) is 100 mg taken about 15 minutes before sexual activity on an as needed basis. Avanafil tablets are taken with or without food.

Based on efficacy and/or tolerability, the dose may be increased to 200 mg taken as early as approximately 15 minutes before sexual activity, or decreased to 50 mg taken approximately 30 minutes before sexual activity. Use the lowest possible dose that provides benefit.

Take Avana tablets no more than once a day. Do not take Avanafil (Generic Stendra) more often than once in any 24 hour period. This means that you can take your next dose only if 24 hours have passed since your last dose. Inform your doctor if Avanafil is not working well or if you experience any side effects.

How Does Avanafil (Generic Stendra) Work?

Avanafil (Generic Stendra) works by helping the blood vessels in your penis to relax. This increases the blood flow into your penis, helping it stay hard and erect when you get sexually excited.

Avana does not cure erectile dysfunction (ED). It is important to note that Generic Avanafil only works if you are sexually stimulated. You and your partner will still need to use foreplay to get ready for sex -just as you would if you were not taking a medicine to help you.

Avanafil Tablets (Avana) Warnings and Precautions

The following warnings and precautions have to be kept in mind before administering Avanafil Tablets (Generic Stendra) :

Cardiovascular Risks:
There is a potential for cardiac risk during sexual activity in patients with pre-existing cardiovascular disease. Therefore, treatments for ED, including Generic Stendra, should not be used in men for whom sexual activity is not advisable because of their underlying cardiovascular status.

Concomitant Use Of CYP3A4 Inhibitors:
Avana metabolism is principally mediated by the CYP450 isoform 3A4 (CYP3A4). Inhibitors of CYP3A4 may reduce Avana clearance and increase plasma concentrations of Avanafil.
For patients taking concomitant strong CYP3A4 inhibitors (including ketoconazole, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, and telithromycin), do not use Generic Avanafil Tablets (Avana).

Prolonged Erection:
Prolonged erection greater than 4 hours and priapism (painful erections lasting more than than 6 hours in duration) have been reported with other PDE5 inhibitors.
In the event of an erection that persists longer than 4 hours, the patient should seek immediate medical assistance. If not treated immediately, penile tissue damage and permanent loss of potency could result.

Generic Avanafil(Avana Tablets) should be used with caution in patients with anatomical deformation of the penis, or in patients who have conditions which may predispose them to priapism (such as sickle cell anemia, multiple myeloma, or leukemia).

Effects On Eye:
Doctors must advise patients to stop use of all PDE5 inhibitors, including Avana, and seek medical attention in the event of a sudden loss of vision in one or both eyes. Such an event may be a sign of non-arteritic anterior ischemic optic neuropathy (NAION), a rare condition and a cause of decreased vision including permanent loss of vision that has been reported rarely postmarketing in temporal association with the use of all PDE5 inhibitors.

Sudden Hearing Loss:
Use of PDE5 inhibitors has been associated with sudden decrease or loss of hearing, which may be accompanied by tinnitus or dizziness. It is not possible at present to determine whether these events are related directly to the use of PDE5 inhibitors or to other factors. Any patient that experiences these symptoms should be advised to stop taking Avana Tablets(Generic Avanafil) and seek immediate medical attention.

Alpha-Blockers And Other Antihypertensives:
Doctors must discuss with patients the potential for Avanafil (Generic Stendra) to increase the blood pressure-lowering effect of alpha-blockers and other antihypertensive medicines. In certain patients, concomitant use of these two drug classes can lower blood pressure significantly leading to symptomatic hypotension (e.g., dizziness, lightheadedness, fainting).

Counseling Patients About Sexually Transmitted Diseases:
The use of Generic Avanafil Tablets (Avana) offers no protection against sexually transmitted diseases. Counseling patients about the protective measures necessary to guard against sexually transmitted diseases, including Human Immunodeficiency Virus (HIV), should be considered.

Avanafil Side Effects

The side effects of Avanafil (Avana Tablets) reported by greater than or equal to 2% of patients treated with this medication during clinical trials for use as needed are Headache, Flushing, Nasal congestion, Nasopharyngitis,and Back pain.
The side effects of Avanafil Tablets reported by greater than or equal to 1% of patients and greater than placebo are upper respiratory infection (URI), bronchitis, influenza, sinusitis, sinus congestion, hypertension, dyspepsia, nausea, constipation, and rash.

The following Avanafil side effects occurred in less than 1% of patients in the three placebo-controlled 3-month clinical trials:

  • Body as a whole - edema peripheral, fatigue
  • Cardiovascular - angina, unstable angina, deep vein thrombosis, palpitations
  • Digestive - gastritis, gastroesophageal reflux disease, hypoglycemia, blood glucose increased, alanine aminotransferase increased, oropharyngeal pain, stomach discomfort, vomiting
  • Musculoskeletal - muscle spasms, musculoskeletal pain, myalgia, pain in extremity
  • Nervous - depression, insomnia, somnolence, vertigo
  • Respiratory - cough, dyspnea exertional, epistaxis, wheezing
  • Skin and Appendages - pruritus
  • Urogenital - balanitis, erection increased, hematuria, nephrolithiasis, pollakiuria, urinary tract infection

 

Generic Avanafil Tablets (Avana) and Alcohol

Patients should be informed that both alcohol and PDE5 inhibitors including Generic Avanafil act as vasodilators. When vasodilators are taken in combination, blood-pressure-lowering effects of each individual compound may be increased.

Therefore, doctors must inform patients that substantial consumption of alcohol (e.g., greater than 3 units) in combination with Avana may increase the potential for orthostatic signs and symptoms, including increase in heart rate, decrease in standing blood pressure, dizziness, and headache

Avanafil Overdosage

Single doses up to 800 mg of Avanafil tablets have been administered to healthy subjects, and multiple doses up to 300 mg have been given to patients.

In cases of overdose, standard supportive measures should be taken as required. Renal dialysis is not expected to accelerate clearance because Avanafil is highly bound to plasma proteins and is not significantly eliminated in the urine.

Avana Tablets Contraindications

Avana tablets are contraindicated in patients with a hypersensitivity to Avanafil or any inactive ingredient present in Avana tablets.

Administration of Avana to patients using any form of organic nitrate is contraindicated. Administration of Avana tablets along with guanylate cyclase (GC) stimulators, such as riociguat are also contraindicated.

Avanafil During Pregnancy

Avanafil has been classified by the US FDA as Pregnancy Category C. Generic Avanafil Tablets (Avana) is not indicated for use in women. There are no adequate and well-controlled studies of Avanafil tablets in pregnant women.

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