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Saizen HGH Injection 3.33 mg Merck Serono Pack of 1 vial of freeze dried powder + 1 vial of solvent

Saizen HGH injections are manufactured by Merck Serono and are administered with the Saizen reconstitution device. The package includes the reconstitution device, 1 vial of Somatropin, 1 cartridge diluent pre-assembled, 1 device housing, and 1 sterile transfer canula.Saizen UsageSaizen is used to treat adults withadult onset GHD or childhood onset GHD. It is also used in the treatment of children suffering from GHD that has led to failure to grow, small for gestational age, Prader-Willi syndrome, Idiopathic Short Stature and Turner syndrome.Saizen Administration and DosageOnce the dose is determined, reconstitute each vial of Saizen® as follows:5 mg vial with 1 to 3 mL of Bacteriostatic Water for Injection, USP (Benzyl Alcohol preserved)8.8 mg vial with 2-3 mL of Bacteriostatic Water for Injection, USP (Benzyl Alcohol preserved)Approximately 10 percent mechanical loss is associated with reconstitution and administration of multi-dose.If there is a sensitivity to the diluent Saizen can be reconstituted using Sterile Water for the Injection.Saizen comes as a powder in a vial along with a cartridge of diluent pre-assembled in a reconstitution device. There are three options available:Saizen 8.8 mg with 1.10 mL of 0.3% metacresol in water for injection. Final concentration that will be injected is 8.0 mg/mL.Saizen 8.8 mg with 1.51 mL of 0.3% metacresol in water for injection. Final concentration that will be injected is 5.83 mg/mL.Saizen 4 mg with 2.66 mL of 0.3% metacresol in water for injection. Final concentration that will be injected is 1.5 mg/mL.Saizen is also available in 1.33 mg, 3.33 mg, 5 mg and 8.8 mg vials, each with vials of diluent, instead of cartridge and without the reconstitution device.Saizen DosesIt’s preferable to inject Saizen in the evening. The dosage and schedule for administration of Saizen will be adapted to your patient’s weight.  Saizen should be administered subcutaneously at a dose of 0.2 mg/kg body weight/week. The dosage can be increased to 0.27 mg/kg/week if there is insufficient response to treatment.Adult GHD: 0.005 mg/kg/day at the start of therapy. After 4 weeks the dose can be increased to 0.01 mg/kg/day if well tolerated.Turner Syndrome: 0.32-0.375 mg/kg/weekChronic Renal Failure 0.35 mg/kg body weight/weekSmall for Gestational Age: Up to 0.47 mg/kg/weekPrader-Willi Syndrome: 0.24 mg/kg/weekSaizen Side EffectsSome side effects of Saizen don’t generally need medical attention. These side effects often go away as your body adjusts to the Saizen. Your doctor may be able provide you with ways to reduce some of these side effects if they are bothersome.Most CommonBody aches or painHeadacheRednessSwellingItchingPainBruisingPain in the arms/legsJoint stiffnessJoint painMuscle painCold symptoms – sneezing, sore throat, stuffy noseThe following are more serious side effects and you should see your doctor immediately.Increased thirstSevere pain in the upper stomach that spreads to the lower backFast heart rateNauseaVomitingHungerIncreased urinationDry mouthDry skinFruity breath odorBlurred visionSwelling in your head, hands, feet, faceWeight lossSudden and severe pain behind your eyesChanges in visionNumbness/tingling in your hand, fingers or wristsGet emergency help immediately if any of the following symptoms of overdose occur while you are taking Saizen:HivesSwelling of the face, tongue, throat, lipsDifficulty breathingImportant Safety InformationShortly after using Saizen, you may feel shaky or light headed as a result of low blood sugar levels. The feeling will disappear quickly.If the patient suffers from a bad or recurrent headache, or from problems with eyesight and vomiting or feeling sick, contact your doctor immediately. Occasionally, brain swelling may develop and the doctor may want to examine the patient’s eyes to look for any sign of this.Deaths have been reported with the use of HGH in children with Prader-Willi syndrome. These children had breathing problems, lung infection and/or were extremely overweight. All patients with Prader-Willi syndrome should be examined for these issues.In adults with GHD, side effects included joint or muscle pain, fluid retention, stiffness, and changes in sensation. Generally, these side effects aren’t long lasting and are linked to the Saizen dosage.Patients with preexisting tumors or growth hormone deficiency secondary to an intracranial lesion should be examined routinely for progression or recurrence of the underlying disease process.Growth Hormone Should Not be Used:To increase the height of children after the growth plates have closed.In patients with diabetes who have certain types of diabetic retinopathy.In patients with cancer or who are being treated for cancer.In patients who are critically ill because of trauma, surgery, or respiratory failure.If it is shown that a previous brain tumor has returned or is getting larger.If you have had an allergy or previous bad reaction to Somatropin or any Saizen ingredients...


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