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Asthma Tab  Salbutamol 2 mg (100 tablet) Tittico Co.

DOSAGE FORM Tablets COMPOSITION Each tablet contains: active ingredient: salbutamol (as sulfate)- 2 mg; inactive ingredients: microcrystalline cellulose, magnesium stearate, talc purified, aerosil 200. CHEMICAL NAME AND CAS NUMBER Bis[(1RS)-2-[(1,1-dimethylethyl)amino]-1-[4-hydroxy-3-(hydroxy methyl)phenyl]ethanol] sulphate; 51022-70-9. PHARMACOLOGICAL GROUP AND ATC CODE Selective, short-acting β2-agonist; R03AC02. PHARMACOLOGY Beta adrenoagonists with a predominant effect on beta2-adrenergic receptors (localized, particularly in the bronchi, myometrium, blood vessels). Prevents and reduces or eliminates bronchospasm, reduces the resistance in the airways, increases the vital capacity. It prevents the release of histamine, slow reacting substance from mast cells and factors chemotaxis of neutrophils. Compared with other drugs of this group has a less pronounced positive chrono-and inotropic effect on myocardium. It widen of coronary arteries, practically does not reduce blood pressure. Has tocolytic effect, lowering the tone and the contractile activity of the myometrium. PHARMACOKINETICS Salbutamol is readily absorbed from the gastrointestinal tract. It is subject to first-pass metabolism in the liver and possibly in the gut wall; the main metabolite is an inactive sulfate conjugate. Salbutamol is rapidly excreted in the urine as metabolites and unchanged drug; there is some excretion in the faeces. Salbutamol does not appear to be metabolised in the lung, therefore its ultimate metabolism and excretion after inhalation depends upon the delivery method used, which determines the proportion of inhaled salbutamol relative to the proportion inadvertently swallowed. It has been suggested that most of an inhaled dose is swallowed and absorbed from the gut. The plasma half-life of salbutamol has been estimated to range from 4 to 6 hours. THERAPEUTIC USES Salbutamol is used as a bronchodilator in the management of reversible airways obstruction, as in asthma and in some patients with chronic obstructive pulmonary disease. ADMINISTRATION Generally treatment begins with the application of salbutamol inhalation form. When inhalation is ineffective, Salbutamol may be given inside. Adult and children over 12 years: 2-4 mg every 6-8 hours , if necessary, the dose may be increased to 8 mg every 6-8 hours. Children aged 6 to 12 years: 2 mg every 6-8 hours. Children aged 2 to 6 years: 1-2 mg every 6-8 hours. Elderly and sensitive patients are administered at an initial dose of 2 mg every 6-8 hours. Adverse Effects Nervous system: tremor, inner trembling, tension, headache, dizziness, sleep and behavior disturbances, muscle cramps. Cardiovascular system: palpitations, tachycardia, arrhythmias, peripheral vascular dilatation, ischemic heart disease. Endocrine system: hyperglycemia Gastrointestinal system: nausea, vomiting. Allergic reactions: rarely - paradoxical bronchospasm, urticaria, angioedema, hypotension and collapse. Other: Potentially serious hypokalaemia has been reported after large doses. PRECAUTIONS Salbutamol should be given with caution in tachyarrhythmias and other cardiac arrhythmias, arterial hypertension, myocarditis, heart defects, aortic stenosis, diabetes, thyrotoxicosis, glaucoma, acute heart failure (with careful medical supervision). Increasing the dose or frequency of receiving salbutamol should be under the supervision of a physician . Shorter interval is possible only in exceptional cases and should be strictly justified. In severe forms of asthma salbutamol should be used in combination with other drugs. In severe asthma particular caution is also required to avoid inducing hypokalaemia as this effect may be potentiated by hypoxia or by concomitant use of other anti-asthma drugs; plasma-potassium concentrations should be monitored. CONTRAINDICATIONS - The risk of miscarriage in I and II trimesters of pregnancy, premature birth - Children under 2 years old. - Hypersensitivity to salbutamol PREGNANCY AND LACTATION Salbutamol is contraindicated in threatened miscarriage in I and II trimesters of pregnancy , premature birth , multiple pregnancy , heart disease in pregnant women, eclampsia , pre-eclampsia , intrauterine infection, fetal death in utero. It is known whether Salbutamol is distributed into milk, so the prescription of salbutamol during lactation should decide on the termination of breast-feeding. DRUG INTERACTIONS Use of salbutamol and other beta2 agonists with corticosteroids, diuretics, xanthines or in the presence of hypoxia increases the risk of hypokalemia. Salbutamol and non-cardioselective β-receptor blocking medicinal products should not usually be prescribed together, because possible mutual suppression of therapeutic effects. Simultaneous precipitation of theophylline increases the risk of tachycardia and arrhythmia , in particular, supraventricular arrhythmia. IDENTIFICATION White, scored cylindrical tablets, the end surface of which are flat. PRESENTATION Cardboard box containing 24 tablets (1 blister packet with 24 tablets). STORAGE conditions Store at temperature 15-250C, in a dry place, out of the reach of children. Protect from light. EXPIRY DATE 3 years...


Salbutamol 2 mg 100 tablets Sterling Knight

Salbutamol is used to treat wheezing and shortness of breath caused by breathing problems (such as asthma, chronic obstructive pulmonary disease).Presentation100 tablets, each tablet contains 2 mg SalbutamolProtectionhologram with serial NO and verification code1. What Salbutamol tablets are and what they are used forSalbutamol tablets belong to a group of medicines called selective beta-2-adrenergic agonists, which can be used to relax the muscles of the airways and womb. Salbutamol tablets may be used in:asthma, to relieve the narrowing of the airwayschronic bronchitisemphysema2. Before you takeDo not take Salbutamol tablets and tell your doctor if you:are allergic (hypersensitive) to salbutamol or any other ingredients in Salbutamol tablets (see section 6)have threatened abortion (potential miscarriage) during the first six months of pregnancyare taking beta-blockers such as propranololCheck with your doctor or pharmacist before taking Salbutamol tablets if you have:an overactive thyroid gland (thyrotoxicosis).diabetes.a history of heart disease, irregular heart rhythm or angina.Although it is not known exactly how often this happens, some people occasionally experience chest pain (due to heart problems such as angina). Tell your doctor/midwife if you develop these symptoms whilst receiving treatment with salbutamol, but do not stop using this medicine unless told to do so.Taking other medicinesPlease tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Especially:diuretics, guanethidine, reserpine or methyldopa (to treat high blood pressure)monoamine oxidase inhibitors e.g. tranylcypromine (for depression)tricyclic antidepressants e.g. amitriptyline (for depression)beta-blockers such as propranololcorticosteroidstheophylline (for breathing problems).inhaled anaesthetics (advise your doctor or dentist if you are undergoing any dentistry or surgery)digoxin (for heart problems)xanthines such as theophylline, aminophylline (for asthma)medicines for diabetesPregnancy and breast-feedingIf you are pregnant, planning to become pregnant or are breast-feeding tell your doctor or pharmacist before taking this medicine.Sugar intoleranceIf you have been told you have an intolerance to some sugars, contact your doctor before taking this medicine, as it contains a sugar called lactose.Ingredients warningSalbutamol tablets contain carmoisine (E122) which may cause allergic reactions.TestsIf you have severe asthma, your doctor may monitor you more closely by carrying out certain tests.3. How to takeAlways take Salbutamol tablets exactly as your doctor has told you. If you are not sure, check with your doctor or pharmacist.Swallow the tablets with waterIf you notice the tablets are not working as well as before, contact your doctor for advice.Adults:Usual dose is 4mg three or four times a day. Your doctor may increase this gradually up to a maximum of 8mg three or four times a day. Some patients may be treated successfully with 2mg three or four times a day.Elderly or patients known to be sensitive to this product or other similar drugs:Initially 2mg three or four times a day should be given.Children 2-6 years:1-2mg three or four times a day.Children 6-12 years:2mg three or four times a day.Children over 12 years:2-4mg three or four times a day.Children under 2 years:Not recommended.If you take more than you shouldIf you (or someone else) swallow a lot of tablets at the same time, or you think a child may have swallowed any contact your nearest hospital casualty department or tell your doctor immediately. Symptoms of an overdose include low levels of potassium in the blood which may cause muscle twitching or weakness and an irregular heart beat.If you forget to take the tabletsDo not take a double dose to make up for a forgotten dose. If you forget to take a dose take it as soon as you remember it and then take the next dose at the right time.4. Possible side effectsStop taking Salbutamol tablets and contact your doctor at once if you experiencean allergic reaction such as swelling of the face, lips, throat or tongue, pale or red irregular raised patches with severe itching (hives), difficulty breathing, low blood pressure, collapsechest, jaw or shoulder pain (which may be accompanied with shortness of breath, feeling or being sick)Tell your doctor if you notice any of the following effects or if you notice any not listed:increased lactic acid in the body: rapid breathing, being sick, stomach painlow blood potassium: muscle twitching or weakness, an irregular heart beatother: headaches, increased blood sugar levels, slight shaking (usually of the hands), a tense feeling, widening of blood vessels which can cause an increase in heart function and heart rate, an irregular heart beat, muscle spasm, fluid on the lungs. An increase in the amount of acid in the body (ketoacidosis) may occur in diabetics.Reporting of side effectsIf you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. 5. How to storeKeep out of the reach and sight of children.Store below 25°C in a dry place.Do not use Salbutamol tablets after the expiry date stated on the label/carton/bottle. The expiry date refers to the last day of that month.Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment...


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